Terbinafine-associated inhibition of dextromethorphan metabolism in Chinese subjects
نویسندگان
چکیده
منابع مشابه
Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Cytochrome P-450 (CYP) 2D6 is responsible for the biotransformation of over 35 pharmacologic agents. In the process of studying CYP2D6 we identified phenotype-genotype discordance in two individuals receiving terbinafine. This prompted evaluation of the potential for terbinafine to inhibit CYP2D6 in vitro. Human hepatic microsomes and heterologously expressed CYP2D6 were incubated with terbinaf...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2001
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2001.01322.x